Eight ancient cities bore this name; the chief, situated on the Lycus, in Phrygia, lay on the way between Ionia and the Euphrates; was a city of great commerce and wealth, the seat of schools of art, science, medicine, and philosophy, and of an early Christian bishopric; though the Church was stigmatised in the Revelation, two councils assembled here in A.D. 363 and 476, the former of which influenced the determination of the canon of both Testaments; the city, destroyed by the Mohammedan invasions, is now in ruins.