The process by which certain exons (coding regions within a gene), under highest suspicion to contain a specific mutation, are subjected to testing via conformation sensitive gel electrophoresis (CSGE), single-stranded conformational-polymorphism (SSCP), denaturing gradient gel electrophoresis (DGGE), or other means deemed most appropriate, to confirm the presence of a mutation before use of further testing, such as sequencing, to delineate the exact nature of the mutation; used to expedite analysis when the disorder in question can be caused by numerous possible mutations within a gene.